The FDA-approved prescribing information says that lamotrigine “should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.” The “potential benefit” is generally the mother’s mental health condition.
Can lamotrigine cause birth defects?
Most studies find no increase in birth defects among women taking lamotrigine in the first trimester of their pregnancy. There have been several large studies (looking at several thousand pregnancies) that have found no increase in birth defects.
Can Lamictal cause a miscarriage?
Can taking lamotrigine in pregnancy cause miscarriage or stillbirth? There is currently no proof that lamotrigine use in pregnancy causes miscarriage or stillbirth.
Does Lamictal cross the placenta?
The study, which assessed neurodevelopmental symptoms up to the age of 12 years, is the most extensive long term report regarding children whose mothers took lamotrigine during pregnancy. Lamotrigine has a good tolerability and safety profile, but is known to cross the placenta.
Which mood stabilizers are safe during pregnancy?
For many women with bipolar disorder, lamotrigine (Lamictal) is an effective mood stabilizer. Given its relatively favorable reproductive safety profile, lamotrigine is a reasonable option for women who require treatment with a mood stabilizer during pregnancy.
What pregnancy category is lamotrigine?
Safety of Psychiatric Medications During Pregnancy and Lactation
|Drug||FDA pregnancy category*|
|Valproic acid (Depakene)||D|
Does folic acid affect lamotrigine?
A secondary analysis suggested that folic acid administration might dampen lamotrigine’s antidepressant effect. The researchers concluded that the combination of lamotrigine and folate should be avoided, and cautioned about the potential effect of widespread folic acid fortification on lamotrigine’s efficacy.
How safe is lamotrigine?
Lamotrigine (Lamictal) has been associated with a rare, but serious and life-threatening adverse reaction called hemophagocytic lymphohistiocytosis (HLH), which can lead to multi-organ failure resulting in hospitalization or death, particularly if diagnosis and treatment are delayed.
What happens if you stop taking lamotrigine?
If you suddenly stop taking lamotrigine, you may experience seizures. If you do stop taking lamotrigine for any reason, do not start taking it again without talking to your doctor.
Does Lamictal affect fertility?
There’s no firm evidence that lamotrigine affects female fertility. For some men with epilepsy, epilepsy medicines can reduce their levels of testosterone. It does not affect everyone, but it could make you less fertile.
Does Lamictal cause weight gain?
Unlike most mood stabilizers, though, Lamictal is less likely to cause weight gain. In clinical trials, less than 5 percent of those taking Lamictal gained weight. If you take Lamictal and have gained weight, the weight gain may be an effect of the disorder itself.
Does Lamictal deplete folic acid?
Lamotrigine has weak folate properties in vitro, but does not appear to have any effect on serum or red blood cell folate levels in humans (as observed in 14 patients on short-term treatment and in an additional 14 patients treated for up to 5 years).
Can lamotrigine affect your period?
Tell your doctor right away if you have unusual changes in your menstrual cycle such as breakthrough bleeding while taking lamotrigine and birth control pills or other female hormonal products.
Can you take bipolar medication while pregnant?
Bipolar Medications During Pregnancy. Some women continue taking bipolar medications and have healthy babies. But a few bipolar medications have an increased risk of birth defects in the first trimester.
Can mood stabilizers affect pregnancy?
Mood stabilizers, such as divalproex-sodium (Depakote) or lithium (Eskalith), may be dangerous to a developing fetus. The precise effects are unclear, however.
Should a bipolar woman have a baby?
Most women with bipolar disorder have a healthy pregnancy and baby, but there are some risks to be aware of. You may become unwell during your pregnancy, but the risk is higher after you give birth. Women with bipolar disorder are more likely to get: postnatal depression.